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Using a peptide-conjugated photosensitizer targeting neuropilin-1, induction of tissue factor expression immediately post-treatment, led to the establishment of thrombogenic effects within the vessel lumen.

Two moderately contaminated freshwater sediments (Sorel Harbour, St. Lawrence River, Canada) were subjected to a suspension event. The objective was to assess the environmental impact of the disposal of dredged material in water, in particular, the short-term effects of dumping on the water column and the long-term effects of dredged sediment deposits. In a series of microcosms, the sediments were left to stand for 25 d under flow-through conditions (reference conditions). In a second series of microcosms, sediments were vigorously suspended for 15 min before being left to settle and were submitted to the same treatment as reference sediments during the following 25 d. Physicochemical and biological parameters (Daphnia magna and Hydra attenuata survival) were measured in overlying water throughout the experiment. Sediment toxicity was assessed with Chironomus tentans and Hyalella azteca exposed to sediments collected at both the beginning and end of the 25-d period. Pore-water toxicity was evaluated with D. magna. During the suspension process, in the Sorel Harbour mixed sediment overlying water, we observed effects on H. attenuata survival and ammonia and metals (chromium, copper, and zinc) releases. Meanwhile, in reference (nonmixed) and mixed sediments as well as in associated pore waters, there were no significant chemical modifications nor biological effects after the 25-d experiments. The developed approach, which attempts to simulate a dumping process, aims at allowing the assessment of the short-and long-term hazards resulting from a resuspension process in overlying water and in resettled sediments using both chemical and biological measurements.

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Mettre les polythéismes en formules ? À propos de la base de données Mapping Ancient Polytheisms Résumé : Cet article présente la Base de Données (BDD) développée dans le cadre du projet ERC Mapping Ancient Polytheisms (MAP), qui vise à étudier les systèmes religieux des mondes grecs et ouest-sémitiques dans la longue durée (ca. 1000 av.-400 ap. J.-C.) à travers le prisme des « attributs onomastiques divins ». On entend par là les noms, épithètes, formes verbales, et autres appellations que les Anciens attribuaient à leurs dieux. La construction d'un tel outil, qui n'est pas sans précédents mais qui s'efforce de franchir un seuil quantitatif et qualitatif, répond à un double impératif : permettre le traitement exhaustif des myriades de dénominations divines en prenant en compte la diversité de contextes dans lesquels elles apparaissent ; utiliser ces dénominations comme les révélateurs des configurations divines et de l'agentivité humaine. La complexité inhérente aux séquences onomastiques divines nécessite l'élaboration d'une base de données soigneusement structurée, souple et précise à la fois. Ainsi, à la suite d'une mise au point terminologique et historiographique, on présente ici la structure de la BDD MAP, et notamment le dispositif d'analyse des formules qui permet la modélisation des séquences onomastiques divines.