The high prevalence of uterine myomas highlights the importance of the diagnosis uterine myomas in standard gynaecological practice: The presence of only one myoma caused symptoms in 46.5% and small myomas of up to 2 cm in diameter resulted in symptoms in 39.5%.

The results of this study suggest that more than 40 % of women over 30 years of age suffered from myomas and more than 50 % of all women in Germany may develop uterine myomas at some time in their life.

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generated a linear plot (slope, 0.0383; r ϭ 0.99; see Fig. 2B in the online Data Supplement), permitting calculation of a conversion factor for ng/L to IU/mL for the DSL assay (26.1 pg/IU).The performance of the two available inhibin A immunoassays was similar with respect to sensitivity, specificity, and precision (data not shown). However, we observed significant differences in the absolute values of inhibin A detected by the two assays. These differences were attributable to differences in the calibrators used in the two assay systems. In light of these issues, the use of a standardized, reference preparation of inhibin A was evaluated. When we used the reference preparation, we obtained identical results for the two assay systems. Given the importance of accurate inhibin A results for antenatal screening and other tests of reproductive physiology, we recommend the use of the WHO IRP for inhibin A for the calibration of inhibin A measurements and for inhibin A concentrations to be reported in IU/mL. These studies were supported in part by NIH Grant HD29164. We gratefully acknowledge the generous contribution of assays by DSL. Sheila Mallette and Joseph Moy provided superb technical assistance. Dr. Jehangir Mistry's contributions to the design and interpretation of these studies while he was employed at DSL are acknowledged and greatly appreciated.

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