We examine the relation between the sounds emitted by the knee joint during walking and its condition, with particular focus on osteoarthritis, and investigate their potential for noninvasive detection of knee pathology. We present a comparative analysis of several features and evaluate their discriminant power for the task of normal-abnormal signal classification. We statistically evaluate the feature distributions using the two-sample Kolmogorov-Smirnov test and the Bhattacharyya distance. We propose the use of 11 statistics to describe the distributions and test with several classifiers. In our experiments with 249 normal and 297 abnormal acoustic signals from 40 knees, a Support Vector Machine with linear kernel gave the best results with an error rate of 13.9%.

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In this work the potential of non-invasive detection of knee osteoarthritis is investigated using the sounds generated by the knee joint during walking. Methods: The information contained in the time-frequency domain of these signals and its compressed representations is exploited and their discriminant properties are studied. Their efficacy for the task of normal vs abnormal signal classification is evaluated using a comprehensive experimental framework. Based on this, the impact of the feature extraction parameters on the classification performance is investigated using Classification and Regression Trees, Linear Discriminant Analysis and Support Vector Machine classifiers. Results: It is shown that classification is successful with an area under the Receiver Operating Characteristic curve of 0.92. Conclusion: The analysis indicates improvements in classification performance when using non-uniform frequency scaling and identifies specific frequency bands that contain discriminative features. Significance: Contrary to other studies that focus on sitto-stand movements and knee flexion/extension, this study used knee sounds obtained during walking. The analysis of such signals leads to non-invasive detection of knee osteoarthritis with high accuracy and could potentially extend the range of available tools for the assessment of the disease as a more practical and cost effective method without requiring clinical setups.

We study the acquisition and analysis of sounds generated by the knee during walking with particular focus on the effects due to osteoarthritis. Reliable contact instant estimation is essential for stride synchronous analysis. We present a dynamic programming based algorithm for automatic estimation of both the initial contact instants (ICIs) and last contact instants (LCIs) of the foot to the floor. The technique is designed for acoustic signals sensed at the patella of the knee. It uses the phase-slope function to generate a set of candidates and then finds the most likely ones by minimizing a cost function that we define. ICIs are identified with an RMS error of 13.0% for healthy and 14.6% for osteoarthritic knees and LCIs with an RMS error of 16.0% and 17.0% respectively.

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