Esophageal cancer has always been subject of research for various studies. According to some authors, esophageal cancer represents the 10th leading cause of cancer in the world with a 5-year survival of 10 %. In terms of anatomopathological form of the esophageal neoplasia, the literature mainly describes two major pathological types: adenocarcinoma and esophageal squamous cell carcinoma. Lately there has been an increased incidence of esophageal adenocarcinoma. The aim of the present work was to study neoangiogenesis in esophageal adenocarcinomas. The study was conducted on 40 cases diagnosed and surgically treated. Subsequently, fragment processing was performed using various immunohistochemical staining and marking with CD34 and p53 antigen. Later, quantitative measurements were performed, and images were taken using a microscope imaging system. In the end of the procedures, the professional program PRODIT 5.2. was applied. The study of the vascular system in the esophageal epithelial tumors revealed an axis consisting of three elements which have a mutual induction process: inflammatory infiltrate-neoangiogenesis-fibrosis, with significant differences between the three degrees of differentiation. A significant increase in tumor micro vascular density was present together with the increasing of the histological grading, with an inverse correlation with the degree of differentiation and directly proportional to the risk of malignancy.

This study assessed the medication used in type 2 diabetes treatment, depending on the glycaemia level and set out the oral anti-diabetics which are recommended, in three study stages: admission, hospitalization and discharge. Eighty patients were selected and diagnosed with diabetes mellitus 2 type, who were registered in the diabetes and nutrition diseases department within Sf. Apostol Andrei Galati Hospital. They were subjected to a series of laboratory tests: blood count, glycosylated haemoglobin, glycaemia level. It were established main classes of anti-diabetic drugs outpatient used and the main types of anti-diabetic agents administrated to patients requiring hospitalization, compared to high glycaemia values. It was given also, the medication used to normalize blood glucose levels during hospitalization and also at discharge. The biguanides associated with sulphonylureas drugs did not provide an adequate glycaemia control, so insulin must be combined with Metformin to normalize blood glucose levels as soon as possible. Glycaemia control was improved and the hypoglycaemia risk was reduced regarding obese patient undergoing treatment with insulin, to whom biguanides were administered.

(1) Background: Pregnant patients with severe forms of coronavirus disease 2019 (COVID-19) can experience adverse pregnancy outcomes. The aim of this study was to retrospectively assess the risk factors associated with admission to the intensive care unit (ICU) of pregnant patients with COVID-19, as well as the pregnancy outcomes of these patients; (2) Methods: Medical records of 31 pregnant patients with COVID-19 admitted to three clinical hospitals from Romania, between October 2020 and November 2021 were examined. The patients were segregated into two groups depending on their clinical evolution: non-ICU admission (n = 19) or ICU admission (n = 12). Clinical and paraclinical findings were evaluated using univariate analysis, and the association of significant risk factors with maternal ICU admission was assessed using a multivariate analysis. Pregnancy outcomes of these patients were also recorded; (3) Results: Pulmonary disease, cough, dyspnea, leukocytosis, thrombocytosis, high serum values of transaminases, serum ferritin, and increased duration of hospital admission were identified as significant risk factors associated with maternal admission to the ICU. No significant differences regarding pregnancy outcomes were noted between the evaluated patients; (4) Conclusions: Specific risk factor identification in pregnant patients with severe forms of COVID-19 could improve the patient’s management.

Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) is a condition characterized by repeated episodes of airway obstruction during sleep, causing intermittent asphyxia and sleep fragmentation. The goal of this study was to assess dream content analysis before and during the first night of treatment for OSAHS using Continuous Positive Pressure (CPAP). We included 38 patients diagnosed using complete overnight polysomnography (PSG), who received CPAP therapy during a second night under PSG. Dream content (word count, thematic units, and emotional content) and the percent of REM sleep were analyzed after both nights. There was an increase in the percent of REM under CPAP (from 16,7% to 26,8%). There was an increase in the number of thematic units (1,36 without CPAP versus 1,82 under CPAP) and in the word count (30,52 without CPAP versus 45,22 under CPAP) and a change in the dream content (unpleasant content in 50% without CPAP versus 37,5% under CPAP). Under CPAP, more patients recalled their dreams than without CPAP (94,2% versus 57,9%). In conclusion, at the initiation of CPAP for OSAHS, there is a rebound of REM sleep associated with a quantitative increase in dream recall and a change in dream content.

Background: Infection with hepatitis B virus (HBV) contributes to morbidity and mortality in people living with human immunodeficiency virus (HIV). Aims:The aim of the present study is to assess the influence of HBV co-infection in clinical characteristics and disease evolution among nosocomial HIV infected youth in Romania.Study Design: Retrospective study. Methods:We assessed HBsAg in 179 young people with nosocomial paediatric HIV infection. Demographic data, ALAT level, CD4-count, HIV-RNA, antiretroviral therapy and clinical behaviour were all statistically compared in patients who were HIV mono-infected and HBV-co-infected. Results:The characteristics of patients are as follows: sex ratio M/F: 55.3%, AIDS category 88%, median nadir CD4-count 126/mm 3 . The prevalence of persistent HBsAg was 44.6%. The mortality rate was 11.1%, but no correlation with HBsAg was found. An average of three antiretroviral combinations is experienced by 97.7% of patients, including Lamivudine for over 5 years in 76% of cases and Tenofovir/Emtricitabine in 16.75% of patients. Patients under antiretroviral therapy achieved 53.07% sustained undetectable HIV-RNA and 40.78% restored immunity CD4-count >500/mm 3 . ALAT enzyme was found to be high in 54.75% of patients.Conclusion: During our research, we noticed that HBsAg was elevated in young people with HIV in Romania. Mortality rate was not statistically correlated to HBsAg. High ALAT levels are related with HBV, HDV co-infections, virological failure to antiretroviral treatment and the risk of death.