Ischemic strokes have varying etiologies and multiple locations. Some locations are much rarer than others and just as difficult to diagnose. This is the case of the ischemic bi-thalamic stroke, attributable to the Percheron artery occlusion that we report in a 33-year-old woman with a history of taking estrogen-progestin. The lesion diagnosis could only be possible thanks to the performance of brain MRI, thus testifying to the diagnostic difficulties observed. Etiological research has shown dyslipidemia. The length of stay was 88 days. At the end of intensive care, the patient was conscious, not deficient and did not present memory disorders.