S orghum [Sorghum bicolor (L.) Moench] is a major cereal crop grown on nearly 42 million ha worldwide for food, fodder, fiber, and fuel (FAOSTAT, 2013). It serves as a staple food crop for millions of people, predominantly in developing countries of Africa and Asia. Among the cereals, sorghum displays exceptional tolerance to heat and drought, and its complex biochemical and morphological characteristics offers an advantage of enhanced C4 carbon assimilation even at high temperatures (Paterson, 2008;Shoemaker et al., 2010). These characteristics make sorghum an attractive crop in both subsistence-and commercial-farming operations. However, a number of biotic and abiotic stresses are known An additional major QTL on chromosome 5 of the SC414-12E genome explained from 20 to 39% of the phenotypic variance and was observed in four of the six environments tested.Resequencing of the genomes of resistant cultivars SC155-14E and SC414-12E facilitated a preliminary survey of the coding regions of genes annotated as playing a role in host defense. The resequenced genomes of the resistant genotypes and the linkage mapping resources represent information relevant for more detailed molecular characterization of genes conditioning anthracnose resistance in this tropical cereal. The identification of QTL conferring anthracnose resistance and the identification of single-nucleotide polymorphisms linked to these loci will provide the necessary molecular tools for markerassisted introgression of durable anthracnose resistance into elite sorghum inbreds.

Our study demonstrates the diagnostic clinical relevance of small, nonrecurrent CNVs <500 kb during CMA clinical testing and underscores the need for careful clinical interpretation of these CNVs.Genet Med 19 4, 377-385.

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