Background:
Sulfur-containing compounds represent an important class of chemical compounds due
to their wide range of biological and pharmaceutical properties. Moreover, sulfur-containing compounds may be
applied in other fields, such as biological, organic, and materials chemistry. Several studies on the activities of
sulfur compounds have already proven their anti-inflammatory properties and use to treat diseases, such as
Alzheimer’s, Parkinson’s, and HIV. Moreover, examples of sulfur-containing compounds include dapsone,
quetiapine, penicillin, probucol, and nelfinavir, which are important drugs with known activities.
Objective:
This review will focus on the synthesis and application of some sulfur-containing compounds used to
treat several diseases, as well as promising new drug candidates.
Results:
Due to the variety of compounds containing C-S bonds, we have reviewed the different synthetic
routes used toward the synthesis of sulfur-containing drugs and other compounds.
A simple and convenient route for the synthesis of thia‐Michael products was established using pyrazol‐5(4H)‐one with various thiophenols in the presence of [Zn(L‐Pro)2],an efficient catalyst under mild reaction conditions. The salient features of this methodology are good yields, eco‐friendly catalyst, low catalyst loading and faster reaction times.
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