Chagas disease is a parasitic disease caused by Trypanosoma cruzi and is also a highly neglected tropical disease. In chronic stages of the disease there may be brain and cardiac inflammation that can lead to death. The nitroxidative effect of cells in response to infection contributes to disease progression by inducing tissue damage. In this systematic review, experiments are presented and discussed that seek to understand the use of antioxidants to combat harmful ROS (reactive oxygen species), in order to reduce oxidative damage to tissue during disease progression. One of the viable forms of therapy to control the chronic form of Chagas Disease are sirtuins, molecules that are part of histone deacetylases (HDAC) of the class III family. The compound presented in this review is resveratrol, which is a natural polyphenol found in grape seeds that acts as a sirtuin 1 agonist (SIRT1), this compound activates SIRT1 during parasitic infections. Studies on SIRT1 are linked to its agonist resveratrol and present a good future perspective for new trypanocidal drugs, as they have a relationship with oxidative stress and an anti-inflammatory effect related to neuroinflammation and cardioprotective effects by preventing cardiac hypertrophy. However, there is a need for clinical tests and studies of Resveratrol in humans to further explore the anti-inflammatory effects that the compound has during the oxidative stress caused by T. cruzi infection. Consequently, this would enable the use of antioxidants, such as Resveratrol, in the treatment of Chagas disease. drugs to control this late inflammation have been researched, since