Background: The association of chronic heart failure (CHF) and iron deficiency (ID) with or without anemia is frequently encountered in current medical practice and has a negative prognostic impact, worsening patients’ exercise capacity and increasing hospitalization costs. Moreover, anemia is common in patients with chronic kidney disease (CKD) and CHF, an association known as cardio-renal anemia syndrome (CRAS) possessing a significantly increased risk of death. Aim: This review aims to provide an illustrative survey on the impact of ID in CHF patients—based on physiopathological traits, clinical features, and the correlation between functional and absolute ID with CHF—and the benefit of iron supplementation in CHF. Method: We selected the most recent publications with important scientific content covering the association of CHF and ID with or without anemia. Discussions: An intricate physiopathological interplay is described in these patients—decrease in erythropoietin levels, activation of the renin-angiotensin-aldosterone system, systemic inflammation, and increases in hepcidin levels. These mechanisms amplify anemia, CHF, and CKD severity and worsen patients’ outcomes. Conclusions: Anemia is frequently encountered in CHF and represents a negative prognostic factor. Data from randomized controlled trials have underlined the administration of intravenous iron therapy (ferric carboxymaltose) as the only viable treatment option, with beneficial effects on quality of life and exercise capacity in patients with ID and systolic heart failure.
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Some theoretical and experimental considerations upon motions developed at hand and wrist levels, for a sample of human subjects without previous pathologies are presented in this paper. Thus, aspects related to the anthropometry of the system wrist-hand-fingers are presented in the first part of the paper, for different categories of subjects out of which the examples used to apply the proposed methodology are selected. The analysis structures required for recording and thermographic evaluation of the hand structure when subjected to controlled effort are presented in the second part of the paper. The third part of the paper is dedicated to the presentation and processing of results and conclusions concerning the thermographic behavior and manifestation of the assembly consisting of wrist-hand-fingers during controlled induced motions.
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