MINICIONAl ANIIIIIS INI lll '91S= IHI All• PURPOSI motT o meet the challenges of a dazzling array of antigens, the B cells of the immune system have developed mechanisms for producing antibodies from more than 10 12 different genetic combinations. Biotechnologists have exploited antibodies' selectivity and specificity-to detect and purify various ligands; to diagnose, treat, and even vaccinate against a wide range of diseases; to bind receptors and catalyze reactions. DiagnosisThe diagnostic use of antibodies dates back four decades to the introduction of precipitin-based methods 1 .

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