Restricted, repetitive behaviors are diagnostic for autism and prevalent in other neurodevelopmental disorders. These behaviors cluster as repetitive sensory-motor behaviors and behaviors reflecting resistance to change. The C58 mouse strain is a promising model for these behaviors as it emits high rates of aberrant repetitive sensory-motor behaviors. The purpose of the present study was to extend characterization of the C58 model to resistance to change. This was done by comparing C58 to C57BL/6 mice on a reversal learning task under either a 100% or 80%/20% probabilistic reinforcement schedule. In addition, the effect of environmental enrichment on performance of this task was assessed as this rearing condition markedly reduces repetitive sensory-motor behavior in C58 mice. Little difference was observed between C58 and control mice under a 100% schedule of reinforcement. The 80%/20% probabilistic schedule of reinforcement generated substantial strain differences, however. Importantly, no strain difference was observed in acquisition, but C58 mice were markedly impaired in their ability to reverse their pattern of responding from the previously high density reinforcement side. Environmental enrichment did not impact acquisition under the probabilistic reinforcement schedule, but enriched C58 mice performed significantly better than standard housed C58 mice in reversal learning. Thus, C58 mice exhibit behaviors that reflect both repetitive sensory motor behaviors as well as behavior that reflects resistance to change. Moreover, both clusters of repetitive behavior were attenuated by environmental enrichment. Such findings, along with the reported social deficits in C58 mice, increase the translational value of this mouse model to autism.

Objective: Behavioral parent training has been proven effective through years of research with a variety of groups. However, little research has been conducted to systematically evaluate the extent to which behavioral parent training may improve parenting skills of foster and other caregivers of dependent children. The Behavior Analysis Services Program (BASP) has been charged with providing behavioral parent training to foster parents and other caregivers of dependent children throughout the state of Florida through a variety of services focusing primarily on a group-class-based training curriculum. This article examines the extent to which behavioral parent training was effective in increasing skills of caregivers who were trained in 2001 and 2002. Methods: Study 1 evaluated skills acquisition via a large-scale analysis of precourse and postcourse assessments, as well as observations of in-home parent-child interactions. Study 2 assessed skills acquisition via controlled analyses using repeated measures and multiple baseline designs. Results: Results showed increases in parenting skills in both studies as a function of curriculum training. Discussion: Implications of the results, limitations, and directions for future research are discussed.

Repetitive behavior refers to a highly heterogeneous set of responses associated with a wide range of conditions, including normative development. Treatment studies for aberrant repetitive behavior are limited although one promising approach involves conceptualizing such behavior as a generalized inflexibility or lack of variability in responding. Relatively little is known about the neurobiological mechanisms that mediate the development and expression of repetitive behavior, information critical to the design of effective pharmacotherapies, early interventions, and prevention strategies. We will review clinical findings in repetitive behavior as well as findings from animal models highlighting environmental factors and the role of cortical-basal ganglia circuitry in mediating the development and expression of these behaviors. Findings from animal models have included identification of a specific neural pathway important in mediating repetitive behavior. Moreover, pharmacological studies that support the importance of this pathway have led to the identification of novel potential therapeutic targets. Expanding the evidence base for environmental enrichment-derived interventions and focusing on generalized variability in responding will aid in addressing the broader problem of rigidity or inflexibility.

The purpose of these studies was to extend the use of stimulus preference assessments to children in foster care. In Study 1, subjects completed a computerized 4-point Likert-type questionnaire designed to assess preference for a wide range of stimuli and activities. Next, items identified as highly preferred (HP) and less preferred (LP) on the questionnaire were tested using a computerized paired-stimulus preference assessment. Results showed complete correspondence between the results of the computerized preference assessments for 11 of 17 subjects. Studies 2 and 3 evaluated whether the stimuli identified as HP in Study 1 would function as reinforcers. Overall, subjects allocated their engagement to HP items, and those HP items could be used as reinforcers for math problem completion. Collectively, these studies demonstrated that computerized preference assessments may be a feasible method of identifying preferences in the foster care system. Implications for their use in foster care are discussed.