One of the main challenges in cancer modelling is to improve the knowledge of tumor progression in areas related to tumor growth, tumor-induced angiogenesis and targeted therapies efficacy. For this purpose, incorporate the expertise from applied mathematicians, biologists and physicians is highly desirable. Despite the existence of a very wide range of models, involving many stages in cancer progression, few models have been proposed to take into account all relevant processes in tumor progression, in particular the effect of systemic treatments and angiogenesis. Composite biological experiments, both in vitro and in vivo, in addition with mathematical modelling can provide a better understanding of theses aspects. In this work we proposed that a rational experimental design associated with mathematical modelling could provide new insights into cancer progression. To accomplish this task, we reviewed mathematical models and cancer biology literature, describing in detail the basic principles of mathematical modelling. We also analyze how experimental data regarding tumor cells proliferation and angiogenesis in vitro may fit with mathematical modelling in order to reconstruct in vivo tumor evolution. Additionally, we explained the mathematical methodology in a comprehensible way in order to facilitate its future use by the scientific community.

In this paper, we consider a (control) optimization problem, which involves a stochastic dynamic. The model proposes selecting the best control function that keeps bounded a stochastic process over an interval of time with a high probability level. Here, the stochastic process is governed by a stochastic differential equation affected by a stochastic process. This setting becomes a chance-constrained control optimization problem, where the constraint is given by the probability level of infinitely many random inequalities. Since such a model is challenging, we discretize the dynamic and restrict the space of control functions to piecewise mappings. On the one hand, it transforms the infinite-dimensional optimization problem into a finite-dimensional one. On the other hand, it allows us to provide the well-posedness of the problem and approximation. Finally, the results are illustrated with numerical results, where classical model for the growth of a population are considered.