Silicone is any chemical polymer, manufactured in the form of a fluid, resin or elastomer which has a chain formed of alternating silicon and oxygen atoms, in the same way as organic compounds. They are used as polishing, sealing and protective agents. They are also waterproofing, lubricants and in medicine are used as basic material of prostheses. However, it has been reported the application of liquid silicone in body areas for aesthetic improvement.
In the course of its complex life cycle, the parasite Schistosoma mansoni need to adapt to distinct environments, and consequently is exposed to various DNA damaging agents. The Schistosoma genome sequencing initiative has uncovered sequences from genes and transcripts related to the process of DNA damage tolerance as the enzymes UBC13, MMS2, and RAD6. In the present work, we evaluate the importance of this process in different stages of the life cycle of this parasite. The importance is evidenced by expression and phylogenetic profiles, which show the conservation of this pathway from protozoa to mammalians on evolution.
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