Caries-affected dentin could remain during conservative preparation for indirect restorations. However, the reduced bond strength of adhesive luting agents to this altered substrate might affect the longevity of restorations. SUMMARYIntroduction: The aim of this study was to evaluate the bond strength of adhesive luting agents to caries-affected dentin (CAD). Methods: Forty human molars were sectioned to create dental slices presenting exposed occlusal dentin. Half of the samples were submitted to eight caries-induction demineralizing/mineralizing cycles. The pH-cycling model consisted of three hours in a demineralizing solution followed by 45 hours of immersion in a mineralizing solution. Dentin hardness was measured before and after the pH cycling. Resin cement cylinders were built up over the dentin surface using RelyX Unicem or RelyX ARC/ Scotchbond Multipurpose Plus. The cement cylinders were submitted to shear load, and the data were analyzed using two-way analysis of variance (ANOVA) and Tukey test (p,0.05).