A non‐oxidant and metal‐free strategy for synthesizing iso‐coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o‐(1‐alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by‐products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot‐scale experiment.

An oxidant-free electrochemical regioselective chlorination of 8-aminoquinoline amides under ambient temperature in batch and continuous-flow was achieved. Inert DCM was used as the chlorinating reagent. Attributing to the continuous-flow setup,...

Minisci-type reaction is one of the important means to construct C­(sp3)–H functionalization of heteroarenes. According to traditional methods, stoichiometric amounts of precious transition metal catalysts and chemical oxidants were required at high temperatures. Here, a green and gentle novel Minisci-type method was developed via visible-light-induced cross-dehydrogenative coupling of heteroarenes with aliphatic C­(sp3)–H bonds under oxidant-free and transition-metal-catalyst-free conditions. Only the catalytic equivalent of CF3SO2Na and room temperature were required to maintain an efficient reaction.

A strategy for electrochemically synthesizing selenium benzoxazines through o-vinylaniline and diselenide has been developed. This metal-free and oxidant-free electrochemical synthesis method is carried out in an undivided cell under mild conditions, which is more environmentally friendly. Moreover, a variety of selenium-substituted benzoxazine can be prepared in good yield with a broad scope and functional group tolerance, which has potential industrial application value.