The effect of surges in COVID-19 caseload on COVID-19 survival rates is unclear, especially independent of temporal changes in survival. This retrospective cohort study used data from a large U.S. hospital database to study the association between caseload surges and risk-adjusted mortality in patients with COVID-19.

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Rationale: Observational studies suggest obesity is associated with sepsis survival, but these studies are small, fail to adjust for key confounders, measure body mass index (BMI) at inconsistent time points, and/or use administrative data to define sepsis. Objective: To estimate the relationship between BMI and sepsis mortality using detailed clinical data for case detection and risk-adjustment. Design: Retrospective cohort analysis of a large clinical data repository Setting: 139 hospitals in the United States of America Patients: Adult inpatients with sepsis meeting Sepsis-3 criteria Exposure: BMI in six categories: underweight (BMI<18.5kg/m 2), normal-weight (BMI=18.5-24.9kg/m 2), overweight (BMI=25.0-29.9kg/m 2), obese-class-I (BMI=30.0-34.9kg/m 2), obeseclass-II (BMI=35.0-39.9kg/m 2), and obese-class-III (BMI≥40kg/m 2). Measurements: Multivariate logistic regression with generalized estimating equations to estimate the effect of BMI category on short-term mortality (in-hospital death or discharge to hospice) adjusting for patient, infection, and hospital-level factors. Sensitivity analyses were

This is the first study to globally assess the human skin transcriptional response during early Lyme disease. Borreliella burgdorferi elicits a predominant IFN signature in the EM lesion, suggesting a potential mechanism for spirochetal dissemination via IDO1-mediated localized immunosuppression.