The results suggest that postpartum depression is a heterogeneous entity and that misdiagnosis of bipolar disorder in the postpartum period may be quite common. The findings have important clinical implications, which include the need for early detection of bipolarity through the use of reliable and valid assessment instruments, and implementation of appropriate prevention and treatment strategies.

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Recent studies have focused on the impact of postpartum depression on breastfeeding; however, the role of breastfeeding and weaning in the onset of postpartum depression has not been adequately studied. This article describes the case of a woman who had 3 episodes of major depression, each following closely the cessation of breastfeeding. The clinical and research implications of the association between weaning and the onset of postnatal depression are discussed.

We describe the case of a patient with refractory bipolar II depression who developed tolerance to lamotrigine and after failing to respond to dose escalation showed a robust response to a retrial of lamotrigine following a two week drug holiday.