Native American young adults residing in urban communities are particularly vulnerable to substance use. After leaving high school, the pressures and stress of continuing education, finding employment, and the responsibilities related to family and tribal community obligations predispose these young adults to substance use. This study used a pre/post test design to evaluate a cultural‐based Talking Circle intervention for the prevention of substance use among urban Native American young adults, ages 18–24. Three measures were used that included the Native‐Reliance Questionnaire, the Indigenous‐Global Assessment of Individual Needs (I‐GAIN) Substance Use Scale, and the Patient Health Questionnaire (PHQ‐9) measure for severity of depression. Findings revealed that participants demonstrated a higher sense of Native‐Reliance, decrease in substance use, and a decrease in the PHQ‐9 depressions scores from baseline to 6‐month postintervention. These findings validate the importance of cultural‐based interventions for the prevention of substance use among urban Native American young adults.

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