Using terahertz time-domain spectroscopy, we report the principal values of absorption coefficients and refractive indices as a function of wavelength between 0.5 and 2.0 THz of eight attractive nonlinear crystals: YCOB, BNA, LBO, CSP, AGS, CdSe, ZnO and GaP. From these data, we calculated the coherence length and phase-matching conditions associated to the emission of a THz wave from a second-order difference-frequency generation.

We performed simulations and experiments of wavefront distortions induced by propagating through diode-pumped square-section amplifying laser rods of Nd-doped phosphate glass and 0.5 % N d : 5 % L u : C a F 2 . We observed that depending on the material, wavefront distortions’ profile can vary from a circular lens-like distortion to a complex astigmatic distortion. We showed that this difference comes from the relative sign of piezo-optic tensor coefficients.

Samarium-153 is a promising theranostic radionuclide, but low molar activities (Am) resulting from its current production route render it unsuitable for targeted radionuclide therapy (TRNT). Recent efforts combining neutron activation of 152Sm in the SCK CEN BR2 reactor with mass separation at CERN/MEDICIS yielded high-Am 153Sm. In this proof-of-concept study, we further evaluated the potential of high-Am 153Sm for TRNT by radiolabeling to DOTA-TATE, a well-established carrier molecule binding the somatostatin receptor 2 (SSTR2) that is highly expressed in gastroenteropancreatic neuroendocrine tumors. DOTA-TATE was labeled with 153Sm and remained stable up to 7 days in relevant media. The binding specificity and high internalization rate were validated on SSTR2-expressing CA20948 cells. In vitro biological evaluation showed that [153Sm]Sm-DOTA-TATE was able to reduce CA20948 cell viability and clonogenic potential in an activity-dependent manner. Biodistribution studies in healthy and CA20948 xenografted mice revealed that [153Sm]Sm-DOTA-TATE was rapidly cleared and profound tumor uptake and retention was observed whilst these were limited in normal tissues. This proof-of-concept study showed the potential of mass-separated 153Sm for TRNT and could open doors towards wider applications of mass separation in medical isotope production.

We performed the direct measurement of second harmonic generation and sum frequency generation phase-matching directions in the organic N-benzyl-2-methyl-4-nitroaniline crystal over its visible and near-infrared transparency range. The fit of these data allowed us to refine the Sellmeier equations of the three principal refractive indices in this range. With these equations, we improved the calculated tuning curves of terahertz emission from a phase-matched difference frequency process. We also determined the absolute magnitude of the d nonlinear coefficient.