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Preparation of Optically Active 1-Aminoalkylphosphonic Acids by Stereoselective Enzymatic Hydrolysis of Racemic N-Acylated 1-Aminoalkylphosphonic Acids.-The preparation of the racemic title compounds (IV) is described. Enzyme catalyzed hydrolysis of these using penicillin acylase proceeds in high enantioselectivity to afford the R-configurated enantiomers (V) in high yields and optical purities along with the protected (S)enantiomers (VI). Deprotection of these gives the S-configurated enantiomers (V). The kinetics of the enzymatic hydrolysis are investigated with the aim of optimization. -(SOLODENKO, V. A.; KASHEVA, T. N.; KUKHAR, V. P.; KOZLOVA, E. V.; MIRONENKO, D. A.; SVEDAS, V. K.; Tetrahedron 47 (1991) 24, 3989-3998; A. N.