This research aims to realize the adaptive and productive capacity of calves with immunotropic agents PS-6 and Prevention-N-E. The object of the research was black-and-white calves, which were transferred to individual pens a day after birth and kept there until 30 days of age, then in open-air pavilions until they reached 180 days of age, that is, they were reared using adaptive technology. According to the principle of analogs, 45 calves of 1 day age were selected, were divided into 3 groups: control, 1st experimental, and 2nd experimental. To increase resistance to the pressure of environmental factors and realize the bioresource potential of the adaptive and productive traits of the organism, the calves of the 1st and 2nd experimental groups were injected intramuscularly immunotropic preparations PS-6 and Prevention-N-E respectively, at a dose of 3 ml per animal on the 2nd-3rd and 7-9th days of life. The animals of the control group were not exposed to immunoprophylaxis. The morphological blood profile of calves was studied against the background of the application of biological products. Thus, intramuscular injection of immunotropic agents PS-6 and Prevention-N-E into calves had a positive effect on the morphological blood composition. The number of erythrocytes in the blood of calves of the 1st and 2nd experimental groups at the age of 30 days was significantly higher than the control values by 5.4 and 6.4%, respectively (P<0.01). The concentration of hemoglobin was significantly higher in the blood of the calves of the 1st and 2nd experimental groups, starting from 30 days of age, by 6.3-11.7% and 6.7-14.4%, respectively. White blood counts in the blood of animals of different groups did not have a statistically significant difference. Consequently, the use of immunotropic drugs PS-6 and Prevention-N-E in calves activates the erythrocyte lineage of hematopoiesis, without significantly affecting leukopoiesis. The results of periodic weighing of calves showed that at the age of 60, 90, 120, 150, 180, 360, and 540 days, the live weight of young animals with the injection of the immunotropic agents PS-6 was significantly higher than the control values by 2.6, 3.4, 5.0, 6.2, 7.0, 9.4 and 12.2 kg (P<0.05-0.01), and with the application of Prevention-N- E - by 3.6, 4.8, 6.6, 8.0, 9.0, 12.2 and 16.4 kg, respectively (P<0.05-0.001).
