Summary. In an attempt to estimate the amount of locally produced immunoglobulin in lymph, concentrations of IgGj^, IgGg, IgA, IgM and albumin were measured in lymph collected from various regions of the body of unanaesthetized sheep.In testicular, afferent leg and efferent leg lymph, the lymph:serum concentration ratios for albumin were much greater than the corresponding ratios for the immunoglobulins. It was found that the concentration of the immunoglobulins and albumin was greater in efferent than in afferent leg lymph, suggesting that capillary beds in the node are contributing capillary filtrate of a higher protein concentration than capillary beds drained by the afferent duct.

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spheroidal and polyhedral malignant cells displaying pronounced pleomorphism and numerous mitotic figures. Initially a diagnosis of Hodgkin's disease was considered, but on review it was decided that the appearances indicated an anaplastic secondary carcinoma compatible with a metastasis from a primary breast neoplasm. Because of the absence of a palpable mass in the breast and in view of the patient's age it was decided that immediate mastectomy was not indicated. The right axilla and supraclavicular region were treated by radiotherapy (1,400 rads) but the breast itself was not irradiated. The patient was kept under regular observation. She remained well until 1966, when a small mobile swelling was noted in the left breapt. Mammography showed no abnormality in

. (1975). Thorax, 30,[102][103][104][105][106][107][108][109]. Congenital intrapericardial aneurysms of the left atrium. A patient with congenital intrapericardial aneurysm/diverticulum of the left atrium diagnosed preoperatively is described. A review of the 16 previously reported cases revealed that the majority of the patients present with palpitation and are found to have an abnormal cardiac shadow on chest radiography, as did this patient. The aneurysm appears to cause systemic emboli and paroxysmal or persistent atrial tachyarrhythmias which are often resistant to medical therapy. The presence of the aneurysm is suggested by an abnormal contour of the left cardiac border in the postero-anterior chest radiograph and this can be confirmed by angiocardiography. Surgical excision of the aneurysm is indicated in all patients to prevent the occurrence or recurrence of systemic emboli and atrial arrhythmias. Our patient has remained free of symptoms since her operation 14 months ago.

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