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Цель исследования-разработка метода энтропийно-вероятностного анализа безопасности лекарственных средств и его апробирование на примере терапии липиднормализующими препаратами. Метод энтропийно-вероятностного анализа представляет собой синтез системно-энтропийного и риск-анализа многомерных стохастических систем. Энтропия-комплексная величина, характеризующая меру неупорядоченности (разброса, колеблемости составных элементов; определяется энтропией хаотичности) и организованности (взаимной зависимости всех элементов подсистем; определяется энтропией самоорганизации) системы. Риск-анализ представляет собой моделирование на основе анализа риска возникновения неблагоприятных последствий относительно оптимальных, пороговых и критических для системы значений. Возможности практического применения метода продемонстрированы на малых выборках на примере сравнительной оценки гепатотоксичности при терапии липиднормализующими препаратами разных групп (статины-аторвастатин, симвастатин, ловастатин, флувастатин; фибратыципрофибрат). Анализировались изменения гепатобилиарной системы через 1,5 месяца терапии по подсистемам: общий билирубин, аспартатаминотрансфераза, аланинаминотрансфераза. Для препаратов аторвастатин, симвастатин, ловастатин, флувастатин, ципрофибрат определены: коэффициенты системной энтропийной взаимосвязи (0

Aim. To assess the dynamics of the prevalence of excessive body weight (pre-obesity) and obesity, to identify gender differences among the workers of an industrial enterprise in the period 1994-2010. Methods. Population-based cross-sectional complex preventive studies of 2566 industrial workers (1579 males and 987 females) aged 18-64 years in order to identify the non-infectious diseases were conducted in 1994, 1999 and 2000. Pre-obesity, obesity and other risk factors were assessed according to the criteria of the program on Countrywide Integrated Noncommunicable Diseases Intervention of the World Health Organization and according to Russian recommendations regarding the metabolic syndrome. Results. The prevalence of excessive body weight (35.3%) and obesity (12.2%) in 2010 for males was significantly higher than in 1999 (31.1 and 7.7% respectively), the prevalence of obesity alone among them was significantly higher in 2010 than in 1994. In females the prevalence of obesity in 2010 was significantly higher than in 1999 (26.7 and 19.9% respectively) with no significant differences in the frequency pre-obesity (34.0 and 39.6% respectively). The prevalence of pre-obesity and obesity among females in 2010 did not differ significantly from such in 1994. Conclusion. Revealed was an increase in the prevalence of pre-obesity and obesity in males and females in the period from 1999 to 2010; mean body mass indices and frequency of pre-obesity and obesity in females were significantly higher than in males at all periods of the prospective study.

The possibility of using modern digital educational technologies in the formation of key competencies of a doctor is shown on the example of the entropy-probability model, which is a synthesis of the system-entropy approach and multidimensional risk analysis of stochastic systems. Examples of practical application of this model in preventive medicine are given: analysis of population entropy in the prevention of noncommunicable diseases, comprehensive assessment of the effectiveness and safety of medicines, quantitative assessment of population health with the determination of the contribution of individual risk factors, and systematic analysis of population changes in monitoring risk factors. The introduction of entropy-probabilistic modeling in the educational process will help in the formation of the doctor’s basic universal, professional competencies and systematic clinical thinking.