Human civilizations have used substances to the skin as cosmetic and therapeutic agents for thousands of years. The skin, on the other hand, was not exploited as a drug delivery method until the twentieth century. The term “transdermal” was first used in 1944 by Merriam Webster, indicating that it is a relatively new notion in medicinal and pharmacological practice. Transdermal medicines are doses that are self-contained and distinct. To produce a systemic effect, drugs are delivered through the skin. Without causing any changes in the drug’s plasma concentration Topical application of medicinal medicines has a number of advantages. There are numerous advantages to this technique of drug delivery over traditional oral and invasive approaches. Also, ensure that the fluid is released in a regulated manner. A medication for a long amount of time. As a result, a variety of chemical and physical approaches to transdermal patch development are being investigated.

Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop FDTs with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs, or orally disintegrating tablets, are highly helpful for children and old people who have trouble swallowing standard pills and capsules .This review focuses on lyophilization, moulding, sublimation, and compaction FDT methods, as well as efforts to enhancing FDT qualities, such as spray drying and the usage of disintegrants. Taste-masking technology, experimental disintegration time measurements, and dissolution are also addressed.

Background According to the information gathered from the literature, no technique for UPLC of triamterene and hydrochlorothiazide employing QbD in the formulations has been published. The technique development by incorporating QbD and validating for accuracy, linearity, precision, LOQ, LOD, ruggedness and selectivity as per ICH is part of the work’s modernity. Results Screening investigations led to the selection of cmps. Peak tailing was evaluated as a metric of technique robustness based on these important analytical attributes, namely retention time. With a 0.1 percent OPN: methanol (40:60) mobile phase, a flow rate of 0.3 ml/min, a wave length of 224 nm, an injection volume of 41, and a run time of 6 min, the best chromatographic separation was attained. Conclusions The method was verified using ICH criteria, which ensure a high level of linearity, accuracy, precision, specificity and robustness. As a result, the suggested approach is regarded as a quick and accurate method for estimating triamterene and hydrochlorothiazide at the same time.