A method is described for the determination of amino acids containing thiol and disulphide groups with a cathode-ray polarograph. These compounds can be determined in denatured and deproteinised sera and in serum hydrolysates. The method has been used to follow the reaction between mustard gas and the amino acids. Penicillin can be determined after conversion to penicillamine.The possible applications of the mei hod to investigate the serological diagnosis of cancer and the therapeutic action of amino acids against chemical agents are suggested.AMINO acids containing thiol and disulphide groups have been determined by conventional polarography both directly1>2 and by means of their catalytic waves in ammoniacal cobalt solution^.^

Cholinesterases are inhibited by 2-fluoro-1,3,2-dioxaphosphorinane 2-oxide by a mechanism that involves a slow association step followed by a very slow phosphorylation step. No phosphorylation step was observed for the interaction between acetylcholinesterase and 2-S-[2'-(NN-diethylamino)ethyl]thio-1,3,2-dioxaphosphorinane 2-oxide.

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