A series of S,K-substituted 1-arylcycloheuylamines was prepared mainly by the reaction of an arylmagnesiuni hromide and 1-dialkylaminocyclohexanecarbonitrile. As the cyclopentyl analog could not be obtained by this way, condensation of 1-phenylcyclopentylamine with pentamethylene dibromide in D I I F was tried with success. These compounds were tested for their psychopharmacological properties. 1-[l-( 2-Thienyl)cyclohesyl]piperidine (16) was found to be the most active.The pharmacological properties of 1-( l-phenylcyclohexj 1)piperidine (7)3 (phenyl~yclidine~-~), for which a t the time of this investigatioii only one synthesis has beeii stimulated the exploration of possible preparative routes applicable also to other members of the series. 57 27

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