Groundwater is often the preferred source for human consumption, irrigation and industry. In Algeria, many people count on well water for their drinking water supply and irrigation of agricultural lands; especially in rural areas, which is a strategic reserve of which quality must be assured. Groundwater protection requires the detection of origins of pollution and its consequences on the ecological system. The region of Bouirahas seen water-borne diseases occurrence caused by groundwater pollution, which has led us to look for the origin of this problem. It is considered like a high-risk area because it has recorded a large number of Toxi-food collective, Viral Hepatitis A, typhoid fever and Choléra cases in 2018. The study carried out based on the potential risks to human health and the GIS for a period of eight years (from 2008 to 2015), has allowed us to the elaboration of water-borne disease mapping of the whole region and to find that the most affected municipalitie sare: Bouira, Sour El Ghozlene, Lakhdaria and Ain Bessem .The correlation between these diseases and the irrigated perimeters by wadis is very strong in this municipalities.