No abstract

Diabetes mellitus is a disease of metabolic disorders where human blood contains a high amount of sugar level for a prolonged period. This study aims to simulate how effective sensor based on MRR and SPR for the purpose of diabetes monitoring. The results show that sensor based on MRR and SPR provides the ability to detect low level of glucose concentration as low as 7 mmol/L (0.13%) and the ability to detect resonance shift for very small glucose concentration change. Therefore, the sensor based on MRR and SPR can be used for diabetes monitoring. The sensitivity of the sensor based on MRR and SPR is 85.84 nm/RIU and 116.69 °/RIU respectively. These findings are important for the development of diabetes monitoring based on MRR or SPR.

Kretschmann-based surface plasmon resonance (K-SPR) is suitable for biomolecular sensing which provides label-free and quick detection results with real-time analysis. In this work, we have investigated the effect of graphene oxide (GO) with titanium dioxide (TiO2) thin films that are placed in hybrid above metal layers such as gold (Au), silver (Ag) and copper (Cu) with the presence of chromium (Cr) as an adhesive layer. The thickness of the Au, Ag and Cu metal thin films were optimized to 40, 30 and 30 nm, respectively, with a fixed thickness of GO of 2 nm and TiO2 of 1.9 nm. The sensing was evaluated for SPR excitation at three different visible wavelengths of 633, 670 and 785 nm. The performance of sensing was analyzed based on the reflectance intensity and full-width at half-maximum (FWHM) of the spectrum using the finite-difference time-domain (FDTD) method. The sensitivity was calculated for analyte sensing in dielectric mediums of air versus water. The sensitivity increment percentage (%ΔS) was determined when comparing analyte detection using Cr/metal and Cr/metal/GO/TiO2 sensor structures. The highest sensitivity of 94.51 deg/RIU was achieved for Cr/Cu/GO/TiO2 K-SPR sensor at 633 nm wavelength.