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The synthesis of dl-18-norestrone (11) from the known dl-18-nor-D-homoestrone methyl ether (IVB) is described. The corresponding methyl ether (VIIIB) was shown to be the racemic form of the methyl ether of the compound obtained by alkaline treatment of 18-hydroxyestrone (I), thus confirming the structure of the latter. In the equilibrium mixture of VIIIp and its 13-is0 epimer, the latter predominates in an approximately 2 to 1 ratio.

THE tuberculostatic peptide antibiotics of the capreomycin group, all afford, on acid hydrolysis, a new guanido-amino-acid1 which has been termed capreomycidine. On the basis of its physical and spectral properties it has been tentatively assigned structure (I) or (II).2 We report evidence which corroborates structure (I).The racemic diastereoisomers (I) and (11) were