The problem of early diagnosis of postpartum purulent-inflammatory diseases and prediction of possible septic complications is highly relevant nowadays. However, due to the prevalence of abortive and asymptomatic clinical forms, timely diagnosis of this pathology remains difficult. In this regard, an important task is to find highly informative markers of inflammatory response that would allow to predict the disease course in the shortest possible time and timely initiate etiotropic therapy. This article presents a review of foreign and domestic literature (Web of Science, e-LIBRARY, Scopus, PubMed, RSCI) for the period 2001–2021 devoted to the study of current inflammatory markers and sepsis diagnostic criteria that play the most important role in the diagnosis of postpartum septic complications. Key words: postpartum endometritis, postpartum purulent-inflammatory complications, sepsis, inflammation, interleukins, fluorescence spectroscopy

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Endometriosis remains one of the most topical diseases in current gynecology and is a multifactorial condition with an overgrowth of tissue morphologically and functionally similar to the endometrium outside the uterine cavity. One of the most frequently diagnosed forms of endometriosis is endometrioid ovarian cysts. An important feature of the clinical course of ovarian endometriosis is its negative impact on reproductive function and the recurrent nature of the disease, which may require repeated surgeries with even greater damage to the ovarian tissue. Therefore, the development of a long-term drug treatment strategy for patients with a history of endometrioid cysts aimed at preventing recurrences is urgently needed. According to domestic and foreign clinical guidelines, progestagen hormone therapy is recommended as first-line therapy for such patients. One of the most clinically studied drugs with a favorable efficacy and safety profile proven in numerous studies is dienogest. The paper presents the experience of foreign and domestic authors in conservative therapy in patients with a history of endometrioid cysts using dienogest in terms of recurrence prophylaxis.

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This article presents an overview of foreign and domestic data (Web of Science, e-LIBRARY, Scopus, PubMed) for the period 19982021, devoted to the system of immune protection of the mother and fetus during normal and pathologically occurring pregnancy. According to the results of the analysis of the literature data, changes occurring at the level of cellular and humoral immunity were revealed, and the mechanisms of innate and adaptive immunity, complement systems in such pathologies of pregnancy as miscarriage, threat of termination, preeclampsia, infectious complications were described. A complex system of protection against fetal rejection is a certain regulatory factor in maintaining the immunological balance during the entire gestation period, and a violation in its work underlies the formation of complications of the early and late postpartum period, as well as neonatal pathologies.