A selective, simple and new reversed phase high performance liquid chromatographic method (HPLC) was developed and validated for simultaneous determination of tinidazole (TIN)  and  lidocaine (LID) in the ovule  dosage form in this study. Developed method was performed with gradient elution by getting C18 (250x4.6mm,5µm) reversed phase HPLC column, mobile phase containing 10mM potassium phosphate buffer (pH3.0), acetonitrile at 1.0 mL/min. Temperatures for  column  and autosampler were adjusted at 25Cº. The chromatographic separation was carried out at 220 nm  wavelength. Retention times were found as 6.5 min for LID and 8.2 min. for TIN. The purity of each substance was evaluated  getting a photodiode array detector. The  linearity ranges  were 75.0-195.0 µg/mL for TIN and 25.0-65.0 µg/mL for  LID. The  limit of dedection (LOD) and  the  limit of quantitation (LOQ)  results were  0.05625 µg/mL and 0.225 µg/mL for TIN,  0.01875 µg/mL and 0.075 µg/mL for LID, respectively.  The simple, sensitive and reproducible method was applied for simultaneous determination of TIN and LID in pharmaceutical preparations successfully.