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The incidence of HCV antibodies has been evaluated in 123 chronic hemodialysis (HD) patients (Group A; 55 M and 68 F) and in 37 consecutive HD patients (group B) admitted to our hospitals for acute hepatitis. In group A, HCV antibodies were present in 27% of the patients. 20 of 36 (55%) had previously received blood transfusions. 21 patients (58%) were also positive for HBV Ab. In 8 patients, ALT were significantly increased. In group B, the diagnosis of HCV-related acute hepatitis was made in 11 patients. 8 of them had previously received blood transfusions. Seroconversion occurred 2-3 months after onset of the disease.

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As changes of erythrocyte glutathione metabolism i s a sensitive index of the i n v i v o o x i d a t i v e processes, reduced glutathione /CSH/ , oxidized glutathione/ CSSC/ s t a b i l i t y od CSH and oxidation 3tate o f haemoglobin have been measured. Data$ hd 11 c h i l d r e w i t h acute c e l i a s disease/ ACS/ 11 chlldt.en on gluten f r e e d i e t / CFCD / were compared t o those of 11 c h i l d r e n w i t h n u t r i t i v e i r o n deticiency/ NlDl and t o 11 healthy c h i l d r e n .IS controls. Erythrocyte CSH content of ACD qroup elevated s i g n i f i c a n t l y , the CSSC level decreased compared t o nornlal controls CSSC and CSSCICSH r a t i o n also d i f f e r e d from those o f NID group, and a marked d i f f e r e n c e haa been measured i n glutathione s t a b i l i t y , too. I n ACD group methaenloglobin and haenlicrom were measured. Anomalies of erythrocyte metabolism normaliaed durina the d i e t oeriod. The decreased CSSC/ CSH value of ACD arouD A . r e f e r s t o decreaged a r t i v i t i o f seleoocnzym gluathione peroxidase, a s > g n i f i c a n t selenium deficiency /228*158nq/gHb/ has been proved t o normal controls 14655 136ng/qHb/.Our r e s u l t s suggesL t h a t during gluten challenge ACO p a t i e n t s suffer from chronic oxidant stress which p a r t i a l l y can be explained by the weakness of scavanger system and by seleniunl deficiency. AREA UNDER p H 4 : ADVANTAGES OF 12Y v a n V a n d e n p l a s , A n i t a ~o o s s e n s , M i a M a r i c h a l . A c a d e m i c C h i l d r e n ' s H o s p i t a l F r e e U n i v e r s i t y o f B r u s s e l s . 2 4 H o u r e s o p h a q e a l p H n o n i t o r i n q h a s become t h e p r e f e r r e d t e s t t o . . . q u a n t i f y a c i d g a s t r o -e s o p h a g e a l r e f l u x . A g r e e m e n t h a s b e e n a c h i e v e d t h a t r e f l u x e d a c i d g a s t r i c c o n t e n t i n t o t h e e s o p h a g u s c o n s t i t u t c s a m a j o r c a u s e o f r e f l u x e s o p h a g i t i s . K e t h e r c f o r e c a l c u l a t e d t h e a s a r e a u n e e r p H 4 " (A) i n 5 6 0 c o n s e c u t i v e p f l m o n i t i n i n f a n t s 1-12 m o n t h s o l d , a n d r e l a t e d t h i s p a r a m e t e r t o t h e % t i m e w i t h pf1<4 ( r e f l u x i n - T h e "P." i s r e l a t k d t o t h e R I w h e r e a s a c c o r d i n g t o t h e I 1 1 t h e "A" i n c r e a s e s s i g n i f i c a n t l y ( p < 0 . 0 0 1 ) ; t h e h i g h SD, h o w e v e r , o b t a i n e d i n e a c h g r o u p i l l u s t r a t e s t h e G r e a t v a r i a b i l i t y i n ' A " ( o r a c i d i t y o f t h e r e f l u x e p i s o d e s ) i n a l l g r o u p s . E s o g h a g o s c o p y ( a n d b i o p s y ) w a s p e r f o r m e d i n 1 1 2 i n f a n t s ( 2 0 % ) . S p e c i f i c i t y i n t h e p r e d i c t i o n o f e s o p h a g i t i s w a s h i g h e r f o r t h e "A" ( 8 8 % ) c o m p a r e d t ot h e 31 ( 5 0 8 1 . S e n s i t i v i t y o f b o t h p a r a n l e t e r s w a s c o m p a r a b l e ( 9 6 % v e r s u...