Recently, many studies have been conducted using semiconductor materials to improve the system's sensitivity and spatial resolution. We are able to improve the spatial resolution by using a pixelated parallel-hole collimator with equal hole and pixel sizes. However, pixelated parallel-hole collimator appears to be problematic to manufacture collimator with small holes. Therefore, we presented an idea for a novel parallel-hole collimator with a cadmium telluride (CdTe) pixelated semiconductor detector. The purpose of this study was to evaluate and optimize the novel parallel-hole collimator geometric designs with CdTe pixelated semiconductor detector using GATE simulation program. This detector was modeled on PID 350 (Oy Ajat, Finland). We designed a novel parallel-hole collimator which consists of the two overlapped pixelated parallel-hole collimators.