Abnormality in mitochondria has been suggested to be associated with development of allergic airway disorders. In this study, to evaluate the relationship between mitochondrial reactive oxygen species (ROS) and NLRP3 inflammasome activation in allergic asthma, we used a newly developed mitochondrial ROS inhibitor, NecroX-5. NecroX-5 reduced the increase of mitochondrial ROS generation in airway inflammatory cells, as well as bronchial epithelial cells, NLRP3 inflammasome activation, the nuclear translocation of nuclear factor-κB, increased expression of various inflammatory mediators and pathophysiological features of allergic asthma in mice. Finally, blockade of IL-1β substantially reduced airway inflammation and hyperresponsiveness in the asthmatic mice. These findings suggest that mitochondrial ROS have a critical role in the pathogenesis of allergic airway inflammation through the modulation of NLRP3 inflammasome activation, providing a novel role of airway epithelial cells expressing NLRP3 inflammasome as an immune responder.

Bone scans with Tc.99m.M DP were analysed in 179 patient with various type of malignant tumor who treated in Severance hospital from June 1980 to January 1981.The brief results were fotlows 1. Among the 179 cases, bone scans were positive in 111 cases (62 %), while only 35 cases (34%) were positíve ín roentgenogram.2. In cases of positive bone scans and roentgenograms, there showed significant correlation with bone pain but no correlation with the level of serum calcium and alkaline phosphatase.3. Distribution of metastases sites on b0 ne 5ιan revealed that no specific location in each malignant tumors, but prostate cancer showed some prevalance on pelvic cavity.4. In comparison of bone scan and roentgenogram , abnormal bone scan showed positivity in roent.genogram about 74% and showed negativity about 49%, respectively .As considered above , authors fo und that bone scan was more accurate and sensitive than usual roent.