The review presents modern views on the pathogenesis of acne. The data of foreign and domestic clinical trials to study the efficacy and safety of drugs containing 1% clindamycin and 15% azelaic acid used to treat acne. The mechanisms of the effects of these drugs on the main elements of the pathogenesis of acne. Substantiates the appropriateness of the drug combination of clindamycin and azelaic acid in the treatment of acne patients.

The review covers current concepts of the pathogenesis of acne. It presents the data of international and Russian clinical studies conducted to assess the efficacy and safety of drugs comprising 15% azelaic acid and used for the treatment of acne. The authors describe mechanisms of the effect of azelaic acid on major stages of the pathogenesis of acne. They substantiate the need in basic care in the treatment of acne by the example of products of the JOYSKIN line. The authors discuss the effect of different components of skin care products on the acne-prone skin.

Chronic skin diseases degrade the patients life quality. Presently, topical steroids are the most efficient drugs for the treatment of inflammatory skin diseases. However, there is a risk involved in their application: the patient can develop both systemic and topical adverse effects. As many as 37 patients with atopic dermatitis (including 16 pregnant women) applied an advanced corticosteroid drug topically for two months (uniderm according to an intermittent regimen: for two consecutive days with a time window of five days (twice a week) against the background of daily administration of Emolium, a basic care product. The uniderm administration regimen made it possible to considerably improve the patients skin condition in most of the cases and improve the life quality in patients with atopic dermatitis.

The article generalizes the current concept of reasons and mechanisms of skin barrier affections, presents a method to correct such affections with the use of Emolium basic skin care products and provides results of the efficacy study of the Emolium cosmetic line along with the glucocorticosteroid therapy in patients suffering from atopic dermatitis.

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