Background: Large randomized clinical trials to evaluate analgesic treatments in pediatric surgery patients are challenging to undertake. Regional anesthetic improves postoperative pain in adults, but its benefits on pediatric patients are unclear. Objective: This study examined regional anesthesia’s effectiveness in reducing postoperative pain. The research on the impact of regional anaesthetic on postoperative pain in paediatric surgical patients was searched extensively. Methods: 2,408 pediatric patients from 10 trials were examined. The majority of the publications written between 2013 and 2017 claimed that using regional anesthetics decreased the need for opioids and lessened postoperative pain. A small number of surgical operations did not significantly vary from normal anesthetic administration in terms of postoperative pain relief. Result: For numerous surgical operations (craniectomy, ophthalmologic surgery, otologic surgery, and heart surgery) on children, better regional anesthesia techniques are needed to reduce postoperative pain. In terms of pain, the Trial group's statistically decreased mean values were discovered (p