The aim of the present study was to prepare a liquid dosage form (syrup) of a NSAID (ibuprofen) by mixed solvency technique. The syrup formulation was prepared by using mixed hydrotropic method in which potassium citrate, sodium citrate, potassium acetate and disodium hydrogen phospahte were used as hydrotropes. Glycerine and tween 80 were also used in the formulation. The syrup was prepared by agitation method. At first solubility of the model drug Ibuprofen was identified by dissolving it with different hydrotropes. It was observed that the solubility of ibuprofen increased with increase in concentration of the hydrotropes. However, it is difficult to develop a formulation with very concentration of hydrotropes. Therefore, co-solvent and surfactants were also added to enhance the solubility of the ibuprofen. Glycerine and tween 80 were used along with blends of hydrotropes to increase the solubility of Ibuprofen. The results, showed 3000 times increase in solubility of the ibuprofen drug. Also, the drug content of the prepared formulation was found to be 99.67% which proved the mixed solubilizing technique as a efficient and stable method for development of pharmaceutical dosage forms.

The present work aimed to increase the solubility of poorly water-soluble drug plumbagin using the hydrotropic solubilization technique. Plumbagin is a potent natural product extracted from the plant Plumbago zeylanica L. belonging to the family Plumbaginacea. It can be used to treat rheumatoid arthritis, dysmenorrhea, injury, and cancer. An oral liquid syrup was prepared using caffeine as a hydrotropic agent. The results showed 97 folds increase in the solubility of the plumbagin when caffeine was used as a hydrotropic agent. Moreover, various evaluation tests like pH, refractive index determination, and drug content of the developed syrup were performed. All the results showed satisfactory outcomes and proved that it is possible to create a stable dosage form using the hydrotropic solubilization technique.