Copper(II) complexes having the formula CuL2 {where, L = 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH)} have been investigated on the basis of elemental analysis, molar conductivity measurements, magnetic susceptibility, UV-visible, IR and ESR spectral data. Non-electrolytic nature of the complexes are revealed by molar conductance data. IR spectral data suggested that hydrazones act as tridentate ligands. The spin Hamiltonian, orbital reduction and bonding parameters of complexes are calculated using ESR spectra of complexes. The compounds are screened for their antibacterial activities against Pseudomonas aureoginos and Bacillus cereus. Acetoylhydrazones show more antibacterial activity than the corresponding benzoyl hydrazones. Some of the Cu(II) complexes show more activity than hydrazone ligands.
New hydrazones have been synthesized by condensing 2-acetylthiophene with acetic hydrazide and benzhydrazide. The synthesized hydrazones viz. 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH) are characterized in the light of physicochemical and analytical data. Structures of ATAH and ATBH are confirmed by FT-IR, 1H-NMR and Mass spectral data. The hydrazones are screened for their anti-bacterial activities against E Coli, Bacillus cereus, Staphylococcus aureus and Pseudomonas aureoginos. Acetoyl hydrazones are found to show more antibacterial activity than the corresponding benzoyl hydrazones.
Vanadium(III) complexes having the composition VLCl3 [where L = 2-acetylpyridine acetoylhydrazone (APAH), 2-acetylpyridine benzoylhydrazone (APBH), 2-acetylthiophene acetoylhydrazone (ATAH) and 2-acetylthiophene benzoylhydrazone (ATBH)] have been investigated using physico-chemical and analytical techniques. Molar conductivity data suggested that the complexes are neutral. Structures of all the vanadium(III) complexes are determined based on infrared and UV-visible spectral data. Electronic spectra of vanadium(III) complexes show three peaks suggesting octahedral structure. Comparison of vibrational spectra of hydrazones and complexes suggest that the hydrazones act as
neutral tridentate ligands. The ligands and their vanadium derivatives are screened for their bacteria destroying activity against pathogenic bacterial strains viz. Gram-negative E. coli, Gram-positive Bacillus, Gram-positive Staphylococcus aureus and Gram-negative P. aureoginosa. Bacteria destroying activities of present complexes are comparable to the activity of the streptomycin. Complexes show more activity than their respective ligands in the case of Gram-positive Bacillus and Gram-negative P. aureoginosa.
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