Stem from the promise of stem cells therapeutic potential for a number of diseases, the regenerative medicine is reaching enthusiastic proportions nowadays. Current therapies include drug treatment, lifestyle modification, organ transplantation, RNA interference "breakthrough technology", and stem cell-based therapy. Research on stem cells is a multiplex challenge provoking both the attention and the confusion of biologists, biotechnologists, medical specialists, and politicians. By integrating various approaches of transcriptomics, proteomics and metabolomics, current adipobiology has identified more than 100 secretory proteins that are produced by the adipose tissue. These proteins designated adipokines include growth factors, cytokines, chemokines, neuropeptides and hypothalamic hormones/releasing factors. In addition, the adipose tissue's secretome contains steroid hormones, free fatty acids, prostaglandins, and endocannabinoinds. Moreover, adipose tissue is the source of adipose-derived stem cells (ADSC). Current interest in the ADSC stems from their multilineage differentiation potential, and ease of derivation in larger quantities using less invasive methods, compared with other stem cell types. The possible benefits of ADSC-based therapy may be mediated via cell proliferation/differentiation and/or paracrine mechanisms. The present review, focusing on adipose tissue secretory activity, also highlights the possible implication of ADSC in the therapy of various disorders, particularly neurodegenerative diseases, myocardial infarction and stroke, along with gut and liver diseases.

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In the past decade, nutrition research has undergone an important shift from epidemiology and physiology to molecular biology, adipobiology and genetics, thus launching the science of nutrigenomics. To at molecular level study effects of nutrition on health and disease. The completion of several large genome projects has markedly altered the research agenda by drawing attention to the importance of genes in human nutrition. There has been a growing recognition that micronutrients and macronutrients can be potent dietary signals that influence the metabolic pathways of cells and have an important role in the control of energy, vascular and neuronal homeostasis. Accordingly, nutrition researchers have increasingly started to recognize that gene-environment interactions can be implicated in the pathogenesis of lifestyle-related diseases, particularly cardiometabolic diseases, fatty liver diseases, cancers, and Alzheimer' disease. An adiponutrigenomic insight into life expectancy is also outlined. Overall, the present Dance Round focuses on a mater of nationwide importance for Bulgaria, a country at the epicenter of today's global healthquake, the obesity and related diseases.

We dance round in a ring and suppose, But the Secret sits in the middle and knows.