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VOL. 23 tion presented here could be a useful supplement to the standard methods for determining absolute configuration.In all tables, unless otherwise specified, the rotations were measured in water. A solvent other than water is indicated by the following symbols appearing after the specific rotation value : A-acetonel C-chloroform, E-ethanol, M-methanol, Ppyridine. The epimeric pairs that do not conform to our predictions are underlined.Thirty-nine aminoester hydrochlorides of substituted benzilic and glycolic acids were synthesized. Two of these compounds appear to be more active in experimental animals than atropine in preventing mortality from an anticholinesterase compound and four of them exhibit the highest anticholinergic activity. One compound previously reported offers some advantage over three of these as an anticholinergic.

No abstract