Background: Aquaculture in Ghana is very profitable, but faces sustainability challenges. This paper assessed the impact pathways by which climate change affects the production and profitability of small-scale aquaculture in Ghana. The study analyzed and compared the economic value of smallholder fish farms with and without the incidence of climatic parameters. Methods: Simple random sampling and purposive sampling techniques were used to select the study area and farms. A total of 30 farmers were interviewed using a questionnaire-based interview. Additionally, using document analysis, observation, and data on farms’ production input and output values, the economic impact of climate change on fish farms was assessed. Results: Extreme temperatures, erratic rainfall, floods, drought, storm and erosion are prevalent in fish farms. Available data shows a decrease of 53.4% of small-scale revenue, a 6.9% reduction in small-scale aquaculture value from GH¢ 83,000 to GH¢ 120,000 reducing fish supply by 25%. The findings indicate that the profitability, economic value, and livelihoods of the small-scale aquaculture industry is greatly affected by changes in climate. The incidence of floods, drought, erratic rainfall, erosion, and extreme temperature synergistically induce poverty. The implication on the livelihoods of fish farming households is very alarming and poses a serious threat to food security in the country. Conclusion: Based on the findings, this study concludes that; floods, rainfall temperature, and drought are the major climatic factors affecting the profitability and sustainability of the pond aquaculture industry. The preliminary recommendation is that there is an urgent need to map out flood-free zones close to perennial water bodies to overcome floods and droughts. Planting trees around ponds to create a micro-ecologies ideal for fish culture and also the construction of water storage facilities and proper dyke design would overcome drought and erosion issues. The adaptive capacity of fish-farmers must be built.