Writing Committee for the REMAP-CAP Investigators IMPORTANCE The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.OBJECTIVE To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19. DESIGN, SETTING, AND PARTICIPANTSThe ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or confirmed COVID-19 between March 9, 2020, and January 18, 2021, within at least 1 domain; 2011 critically ill adults were randomized to open-label interventions in the immunoglobulin domain at 129 sites in 4 countries. Follow-up ended on April 19, 2021. INTERVENTIONSThe immunoglobulin domain randomized participants to receive 2 units of high-titer, ABO-compatible convalescent plasma (total volume of 550 mL ± 150 mL) within 48 hours of randomization (n = 1084) or no convalescent plasma (n = 916). MAIN OUTCOMES AND MEASURESThe primary ordinal end point was organ support-free days (days alive and free of intensive care unit-based organ support) up to day 21 (range, −1 to 21 days; patients who died were assigned -1 day). The primary analysis was an adjusted bayesian cumulative logistic model. Superiority was defined as the posterior probability of an odds ratio (OR) greater than 1 (threshold for trial conclusion of superiority >99%). Futility was defined as the posterior probability of an OR less than 1.2 (threshold for trial conclusion of futility >95%). An OR greater than 1 represented improved survival, more organ support-free days, or both. The prespecified secondary outcomes included in-hospital survival; 28-day survival; 90-day survival; respiratory support-free days; cardiovascular support-free days; progression to invasive mechanical ventilation, extracorporeal mechanical oxygenation, or death; intensive care unit length of stay; hospital length of stay; World Health Organization ordinal scale score at day 14; venous thromboembolic events at 90 days; and serious adverse events. RESULTS Among the 2011 participants who were randomized (median age, 61 [IQR, 52 to 70] years and 645/1998 [32.3%] women), 1990 (99%) completed the trial. The convalescent plasma intervention was stopped after the prespecified criterion for futility was met. The median number of organ support-free days was 0 (IQR, -1 to 16) in the convalescent plasma group and 3 (IQR, -1 to 16) in the no convalescent plasma group. The in-hospital mortality rate was 37.3% (401/1075) for the convalescent plasma group and 38.4% (347/904) for the no convalescent plasma group and the median number of days alive and free of organ support was 14 (IQR, 3 to 18) and 14 (IQR, 7 to 18), respectively. The median-adjusted OR was 0.97 (95% credible interval, 0.83 to 1.15) and the posterior probability of futility (OR <1.2) was 99.4% for the convalescent plasma group compared with the no convalescent plasma group. The treatment effects were consistent across the primary outcome and the 11...

Abstract-In this paper, we first verify a previously proposed Kronecker-structure-based narrow-band model for nonline-ofsight (NLoS) indoor multiple-input-multiple-output (MIMO) radio channels based on 5.2-GHz indoor MIMO channel measurements. It is observed that, for the narrow-band case, the measured channel coefficients are complex Gaussian distributed and, consequently, we focus on a statistical description using the first-and second-order moments of MIMO radio channels. It is shown that the MIMO channel covariance matrix can be well approximated by the Kronecker product of the covariance matrices, seen from the transmitter and receiver, respectively. A narrow-band model for NLoS indoor MIMO channels is thus verified by these results. As for the wide-band case, it is observed that the average power-delay profile of each element of the channel impulse response matrix fits the exponential decay curve and that the Kronecker structure of the second-order moments can be extended to each channel tap. A wide-band MIMO channel model is then proposed, combining a simple COST 259 single-inputsingle-output channel model and the Kronecker structure. Monte Carlo simulations are used to generate indoor MIMO channel realizations according to the models discussed. The results are compared with the measured data using the channel capacity and good agreement is found.

This paper presents the analysis of spatial correlation in MIMO channels, calculated from data measured in office environments at 5.2GHz. Results are compared with those from channels generated using a stochastic MIMO channel model and the effect of different comparison metrics is shown. The suitability of the stochastic model under different propagation conditions is also investigated.

Abstract-In this article we present the design of an analog detector for Multiple-Input Multiple-Output (NIMO) wireless systems, based on the well known Belief Propagation (BP) algorithm. BP has been shown to obtain excellent results when solving inference problems in sparsely connected factor graphs. Unfortunately, MIMO detection is an example of inference in a densely connected graph, so other techniques need to be applied. We show that BP in conjunction with simulated annealing can offer near optimal performance when there is enough diversity in the receiver. Interestingly, this algorithm can be easily mapped into analog circuitry, thus leading to potentially low-power area-efficient MIMO detectors. A small analog detector based on this work has been designed and laid out in a 0.25pm BiCMOS process.

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