Abattoirs are vital for gathering information on animal diseases and protecting the public from consuming infected or unhygienic meat. To assess the major reasons for organ and carcass condemnations and their financial implications, we reviewed 10-year abattoir records of slaughtered bovines between January 2005 and December 2014 at Kombolcha ELFORA abattoir, north-east Ethiopia. Of the 46,913 cattle slaughtered during that period, 17,963 (38.3%) had at least one disease condition. Lungs (10.67%) and liver (25%) were the most affected and condemned organs, followed by heart (1.53%), head (0.56%), tongue (0.17%) and kidney (0.32%). The major conditions responsible for condemnation were fasciolosis (49.89%), hydatid cyst (55.55%), pericarditis (78.2%), hydronephrosis (35.8%), abscess (71.7%) and abscess (43.9%), in liver, lung, heart, kidneys, head and tongue, respectively. The direct financial losses incurred from organ and carcass condemnation over the 10-year period amounted to ETB 1,219,399 (USD 61,946.9), with parasitic diseases such as fascioliasis and hydatidosis accounting for ETB 256,837.5 (USD 13,047.64) and ETB 170,827.5 (USD 8678.23) in losses, respectively. This study describes a significant loss of cheap and reliable sources of protein due to non-utilization of infected organs or carcasses, emphasizing the need to implement integrated approaches in disease surveillance and control programmes.