Background: Increased CA-125 concentrations are seen during ovulation and menstruation. It is produced from endometrium and irritation of peritoneum (by infection/surgery/endometriosis). High plasma levels of more than 200 U/mL are usually suggestive of malignancy but rarely found in benign conditions of female genital tract, like endometriosis. Case Report: Two patients with abdominal mass and suspected diagnosis of ovarian malignancy presented with high levels of CA-125. In the first case, endometrioma excision was done with unilateral salpingoophorectomy The second case was treated by hysterectomy with bilateral salpingoophorectomy. A fall in CA-125 levels was observed in both cases, and no recurrence was reported on follow up. Conclusion: Endometrioma should be suspected in adnexal mass with high CA-125, even in the absence of widespread endometriosis.