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Plants have been the basis of many traditional medicines throughout the world for thousands of years and continue to provide new remedies to mankind. They are one of the richest sources of compounds. Berberis aristata is one of the major plants used in Ayurveda for several remedies. It is used as a tonic, alternative, demulscent, diaphoretic and diuretic, and in the treatment of diarrhoea, jaundice, skin diseases, syphilis, chronic rheumatism and urinary disorders. Scientific evidence suggests its versatile biological functions that support its traditional use in the orient. Phytochemical studies shows that plant Berberis aristata contains mainly yellow colored alkaloids Berberine, oxyberberine, berbamine, aromoline, a protoberberine alkaloid karachine, palmatine, oxycanthine and taxilamine and tannins, sugar, starch. Among the several compounds Berberine is main constitute having various pharmacological actions. It is, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous medicinal plants and has an array of pharmacological properties. It has been used in Ayurvedic and Chinese medicine for its antimicrobial, antiprotozoal, antidiarrheal and antitrachoma activity. Moreover, several clinical and preclinical studies demonstrate ameliorative effect of berberine against several disorders including metabolic, neurological and cardiological problems. This review provides a summary regarding the pharmacokinetic and pharmacodynamic features of berberine, with a focus on the different mechanisms underlying its multispectrum activity..

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WASH (water, sanitation, and hygiene) has become the most crucial amenity in the past decade for every individual on the planet. In the UN agenda for 2030, which created 17 Sustainable Development Goals (SDGs), SDGs 3, 4, and 6 directly correlate with WASH practices and management for creating a good health hygiene environment for all. The dearth of WASH facilities has created barriers for averting the transmission of COVID-19, motivating the concept of WASH as the primary step of precaution and prevention, which includes WASH practices, communication for literacy, and positive behavioral changes primarily in developing and low-income countries. This Review deals with the complex concept of correlation of WASH and SDGs 3, 4, and 6 while defining elaborate WASH practices, including the prominence of clean water, the need for sanitation facilities, and health hygiene for good health and immunity for preparedness for and during epidemics and pandemics. Certain risk factors explain the sectors in which the gaps exist, creating a gap for implementation of WASH practices in epidemics and pandemics across the globe. Further, COVID-19 surge succession is presented along with data of different variants that have occurred. The need of WASH understanding is required using different tools (audio-visual, social media, print media, and mass media) and strategies (communication, advocacy, and positive behavioral changes) for every individual as an act to counter consequences during and after the COVID-19 pandemic and as a routine practice for future preparedness. This Review gives a detailed concept of WASH understanding for every sector from community to government agencies and research professionals to act immediately for the sustainable future of humanity.

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