Yeast GID is a 600 kDa protein complex composed of seven proteins that functions as a ubiquitin-ligase complex and participates in the inactivation of gluconeogenesis (Menssen et al. 2012). There are GID-like protein complexes in most Eukaryotes, but not in Prokaryotes (Francis et al. 2013). In humans, the complex is called MRCTLH, from muskelin/RanBP9/CTLH, and is composed of eight proteins that are homologous in domain organization and sequence identity to yeast GID proteins (Maitland et al. 2019). Human MRCTLH also has E3 ubiquitin ligase activity and is involved in various processes including cell signaling (