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The effects of admixtures of potassium bromide (2.5% and 5%) on the thermal decomposition of potassium bromate were studied within the temperature range 653-683 K.The fraction decomposed (~) vs. time (t) relations revealed (i)initial gas evolution,(ii) acceleratory and (iii) decay steps. The data were analysed on the basis of the first-order law with two rate constants kl and k2, kl being the rate constant for the initial, slow first-order process (0.02, 0.26), and k 2 being the rate constant for the subsequent faster process, holding within the range 0.21 to 0.98. Upon increase oftbe concentration of added potassium bromide to 5%, the range for the slow and faster processes became 0.01 to 0.16 and 0.1 to 0.98, respectively. At a given temperature, kl increased with increasing bromide concentration, whereas k2 almost identical for pure potassium bromate and its mixtures (2.5% and 5% bromide).The isothermal decomposition of potassium bromate has been studied in detail by Jach [1]. At low temperatures the decomposition proceeds in the solid phase, whereas at high temperature the substance melts well below the melting point, due to the formation of a eutectic between potassium bromate and potassium bromide. Solymosi [2] observed that the decomposition of potassium bromate was enhanced by the addition of potassium bromide and that the decomposition proceeded in the solid phase in the presence of th e catalyst CuO. The discontinuity observed in the Arrhenius plot was attributed to the melting of potassium bromate during decomposition. The present work deals with the effects of admixtures of potassium bromide (2.5% and 5%) on the thermal decomposition of potassium bromate.

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Background Nonalcoholic fatty liver, or NAFLD, is the most common chronic liver ailment. It is characterized by excessive fat deposition in hepatocytes of individuals who consume little or no alcohol and are unaffected by specific liver damaging factors. It is also associated with extrahepatic manifestations such as chronic kidney disease, cardiovascular disease, and sleep apnea. The global burden of NAFLD is increasing at an alarming rate. However, no pharmacologically approved drugs against NAFLD are available owing to their complex pathophysiology. Genome-wide association studies have uncovered SNPs in the fat mass and obesity-associated gene (FTO) that are robustly associated with obesity and higher BMI. The prevalence of NAFLD increases in parallel with the increasing prevalence of obesity. Since FTO might play a crucial role in NAFLD development, the current study identified five potentially deleterious mutations from 383 ns-SNPs in the human FTO gene using various in silico tools. Methods This study aims to identify potentially deleterious nonsynonymous SNPs (ns-SNPs) employing various in silico tools. Additionally, molecular modeling approaches further studied the structural changes caused by identified SNPs. Moreover, molecular dynamics studies finally investigated the binding potentials of the phytochemicals resveratrol, rosmarinic acid, and capsaicin with different mutant forms of FTO. Results The current investigation has five potentially deleterious mutations from 383 ns-SNPs in the human FTO gene using various in silico tools. The present study identified five nsSNPs of the human gene FTO, Gly103Asp, Arg96Pro, Tyr295Cys, and Arg322Gln, with an apparent connection to the disease condition. Modulation of demethylation activity by phytomolecule scanning explains the hepatoprotective action of molecules. The current investigation also suggested that predicted mutations did not affect the binding ability of three polyphenols: rosamarinic acid, resveratrol, and capsaicin. Conclusion This study showed that the predicted mutations in FTO did not affect the binding of three polyphenols. Thus, these three molecules can significantly aid drug development against FTO and NAFLD.