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The effects on lipolysis of various compounds have been studied in intact chicken adipose tissue and in isolated fat cells prepared from chicken adipose tissue. Glucagon stimulated lipolysis at concentrations down to 1 ng./ml. in intact pieces and 0\ m=. \ 1ng./ml. in isolated fat cells. The effect was enhanced by high concentrations of insulin. No anti-lipolytic effect of insulin was observed. Adrenaline, noradrenaline, porcine corticotrophin (ACTH) and long-acting ACTH were lipolytic but the effects were small and high concentrations were required. The adrenaline effect was blocked by propranolol hydrochloride. Dibutyryl 3\m=' \,5\m=' \-(cyclic)-AMP and theophylline stimulated lipolysis as did a combination of crude chicken growth hormone and hydrocortisone sodium succinate. It was concluded that the pattern of response of chicken adipose tissue was markedly different from that of the rat.

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The relationships between plasma insulin, glucose, non-esterified fatty acid (NEFA) and \g=a\-amino nitrogen concentrations in the domestic fowl have been studied. During a 72-hr. fast the plasma glucose concentration fell while the NEFA concentration rose but there was no change in plasma insulin concentration. Both oral and intracardiac glucose increased the plasma insulin concentration and lowered the plasma NEFA and \g=a\-amino nitrogen concentrations. Oral amino acids increased plasma insulin and glucose concentrations but had no effect on plasma NEFA. Intracardiac ox insulin depressed plasma glucose and \g=a\-amino nitrogen and increased the plasma NEFA concentration. Intracardiac glucagon increased both plasma glucose and NEFA and depressed the plasma \g=a\-amino nitrogen concentrations but had no significant effect on plasma insulin. Intracardiac adrenaline had no effect on plasma NEFA but increased plasma glucose concentration and caused a small depression in plasma insulin concentration.