Aims. To test the dust torus model for active galactic nuclei directly, we study the extent and morphology of the nuclear dust distribution in the Circinus galaxy using high resolution interferometric observations in the mid-infrared. Methods. Observations were obtained with the MIDI instrument at the Very Large Telescope Interferometer. The 21 visibility points recorded are dispersed with a spectral resolution of λ/δλ ≈ 30 in the wavelength range from 8 to 13 µm. To interpret the data we used a stepwise approach of modelling with increasing complexity. The final model consists of two black body Gaussian distributions with dust extinction. Results. We find that the dust distribution in the nucleus of Circinus can be explained by two components, a dense and warm disk-like component of 0.4 pc size and a slightly cooler, geometrically thick torus component with a size of 2.0 pc. The disk component is oriented perpendicular to the ionisation cone and outflow and seems to show the silicate feature at 10 µm in emission. It coincides with a nuclear maser disk in orientation and size. From the energy needed to heat the dust, we infer a luminosity of the accretion disk of L acc = 10 10 L , which corresponds to 20% of the Eddington luminosity of the nuclear black hole. We find that the interferometric data are inconsistent with a simple, smooth and axisymmetric dust emission. The irregular behaviour of the visibilities and the shallow decrease of the dust temperature with radius provide strong evidence for a clumpy or filamentary dust structure. We see no evidence for dust reprocessing, as the silicate absorption profile is consistent with that of standard galactic dust. We argue that the collimation of the ionising radiation must originate in the geometrically thick torus component. Conclusions. Based on a great leap forward in the quality and quantity of interferometric data, our findings confirm the presence of a geometrically thick, torus-like dust distribution in the nucleus of Circinus, as required in unified schemes of Seyfert galaxies. Several aspects of our data require that this torus is irregular, or "clumpy".

We present new interferometric data obtained with mid‐infrared interferometric instrument (MIDI) for the type II Seyfert galaxy NGC 1068, with an extensive coverage of 16 uv points. These observations resolve the nuclear mid‐infrared emission from NGC 1068 in unprecedented detail with a maximum resolution of 7 mas. For the first time, sufficient uv points have been obtained, allowing us to generate an image of the source using maximum entropy image reconstruction. The features of the image are similar to those obtained by modelling. We find that the mid‐infrared emission can be represented by two components, each with a Gaussian brightness distribution. The first, identified as the inner funnel of the obscuring torus, is hot (∼800 K), 1.35 parsec long and 0.45 parsec thick in full width at half‐maximum (FWHM) at a PA =−42° (from north to east). It has an absorption profile different than standard interstellar dust and with evidence for clumpiness. The second component is 3 × 4 pc in FWHM with T=∼300 K, and we identify it with the cooler body of the torus. The compact component is tilted by ∼45° with respect to the radio jet and has similar size and orientation to the observed water maser distribution. We show how the dust distribution relates to other observables within a few parsec of the core of the galaxy, such as the nuclear masers, the radio jet and the ionization cone. We compare our findings to a similar study of the Circinus galaxy and other relevant studies. Our findings shed new light on the relation between the different parsec‐scale components in NGC 1068 and the obscuring torus.

Context. To reveal the origin of mid-infrared radiation from the core of Centaurus A, we carried out interferometric observations with the MID-infrared Interferometer (MIDI) at ESO's VLTI telescope array. Aims. Observations were obtained with four baselines between unit telescopes of the VLTI, two of them roughly along the radio axis and two orthogonal to it. The interferometric measurements are spectrally resolved with λ/∆λ = 30 in the wavelength range 8 to 13 µm. Their resolution reaches 15 mas at the shortest wavelengths. Supplementary observations were obtained in the near-infrared with the adaptive optics instrument NACO, and at mm wavelengths with SEST and JCMT. Methods. The mid-infrared emission from the core of Centaurus A is dominated by an unresolved point source (<10 mas). Observations with baselines orientated perpendicular to the radio jet reveal an extended component which can be interpreted as a geometrically thin, dusty disk, the axis of which is aligned with the radio jet. Its diameter is about 0.6 pc. It contributes between 20% (at λ 8 µm) and 40% (at λ 13 µm) to the nuclear flux from Centaurus A and contains dust at about 240 K. We argue, that the unresolved emission is dominated by a synchrotron source. Its overall spectrum is characterized by an F ν ∼ ν −0.36 power-law which cuts off exponentially towards high frequencies at ν c = 8 × 10 13 Hz and becomes optically thick at ν < ν 1 45 GHz. Results. Based on a Synchrotron Self Compton (SSC) interpretation for the γ-ray emission, we find a magnetic field strength of 26 µT and a maximum energy of relativistic electrons of γ c = E c /m e c 2 = 8500. Near γ c , the acceleration time scale is τ acc = 4 days, in good agreement with the fastest flux variations, observed at X-ray frequencies. Our SSC model argues for a Doppler factor δ 1 whichtogether with the jet-counter jet ratio of the radio jets on parsec scale -results in an upper limit for the bulk Lorentz factor Γ jet < 2.5, at variance with the concept of a "mis-directed BL Lac object". Conclusions. We estimate a thermal luminosity of the core, P th 1.3 × 10 34 W = 1.5 × 10 −4 × L Edd , intermediate between the values for highly efficiently accreting AGN (e.g. Seyfert galaxies) and those of typical FR I radio galaxies. This luminosity, which is predominantly released in X-rays, is most likely generated in an Advection Dominated Accretion Flow (ADAF) and seems just sufficient to heat the dusty disk.

Aims. The emission of warm dust dominates the mid-infrared spectra of active galactic nuclei (AGN). Only interferometric observations provide the necessary angular resolution to resolve the nuclear dust and to study its distribution and properties. The investigation of dust in AGN cores is hence one of the main science goals for the MID-infrared Interferometric instrument MIDI at the VLTI. As the first step, the feasibility of AGN observations was verified and the most promising sources for detailed studies were identified. Methods. This was carried out in a "snapshot survey" with MIDI using Guaranteed Time Observations. In the survey, observations were attempted for 13 of the brightest AGN in the mid-infrared which are visible from Paranal. Results. The results of the three brightest, best studied sources have been published in separate papers. Here we present the interferometric observations for the remaining 10, fainter AGN. For 8 of these, interferometric measurements could be carried out. Size estimates or limits on the spatial extent of the AGN-heated dust were derived from the interferometric data of 7 AGN. These indicate that the dust distributions are compact, with sizes on the order of a few parsec. The derived sizes roughly scale with the square root of the luminosity in the mid-infrared, s ∝ √ L MIR , with no clear distinction between type 1 and type 2 objects. This is in agreement with a model of nearly optically thick dust structures heated to T ∼ 300 K. For three sources, the 10 μm feature due to silicates is tentatively detected either in emission or in absorption. Conclusions. The faint AGN of the snapshot survey are at the sensitivity limit of observations with MIDI. Thus, the data set presented here provides a good insight into the observational difficulties and their implications for the observing strategy and data analysis. Based on the results for all AGN studied with MIDI so far, we conclude that in the mid-infrared the differences between individual galactic nuclei are greater than the generic differences between type 1 and type 2 objects.

Using primary cultures of oligodendrocyte progenitors isolated from male and female neonatal rodent brains, we observed more oligodendrocytes in female-derived compared to male-derived cultures. To determine whether the observed differences were due to a differential effect of sex hormones on proliferation, we treated cultures with increasing doses of 17β-estradiol, testosterone or progesterone and labeled cells with bromodeoxyuridine to identify cells in S phase. Treatment with 17β-estradiol, but not progesterone or testosterone, delayed the exit of oligodendrocyte progenitor cells from the cell cycle. In addition, 17β-estradiol treatment enhanced membrane sheet formation, while progesterone increased cellular branching. Interestingly, the estrogen modulator tamoxifen mimicked the effect of 17β-estradiol on cell cycle exit, but not on membrane formation. Immunocytochemical localization of estrogen receptors (ERs) showed ERβ mainly localized to the cytoplasm of oligodendrocytes, suggesting that the effect of 17β-estradiol on membrane formation could be mediated by interaction with this receptor. We conclude that sex steroids differentially regulate oligodendrocyte progenitor number and myelin formation, possibly contributing to gender-specific differences in repair.