Reperfusion injury is the phenomenon whereby relief of The role of individual cell types in hepatic hypoxiahypoxic ischemia is followed by accentuation rather than rereoxygenation (reperfusion) injury has not been comlief of tissue damage. This paradoxical event is well docupletely defined. We therefore examined the effects of mented in the intact liver and has considerable clinical relehypoxia and hypoxia-reoxygenation on the viability of vance in relation to organ preservation and hepatic surgery. SECs in producing liver cell injury during hypoxia-reoxygen- Received November 8, 1995; accepted July 1, 1996. ation were studied by coculture experiments.Dev